RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Dnmt1
RNA ID
RNA Type
mRNA
Alteration Pattern
dysregulation
Species
mus musculus
Detection Methods
qRT-PCR; Examination of DNA methylation patterns; Dual-luciferase reporter assay etc.
Target
NA
Pathway
NA
PubMed ID
Title
Epigenetic regulation of miR-17~92 contributes to the pathogenesis of pulmonary fibrosis
Year
2013
Function
"Compared with control samples, miR-17~92 expression was reduced in lung biopsies and lung fibroblasts from patients with IPF, whereas DNMT-1 expression and methylation of the miR-17~92 promoter was increased. Several miRNAs from the miR-17~92 cluster targeted DNMT-1 expression resulting in a negative feedback loop. Similarly, miR-17~92 expression was reduced in the lungs of bleomycin-treated mice. Treatment with 5'-aza-2'-deoxycytidine in a murine bleomycin-induced pulmonary fibrosis model reduced fibrotic gene and DNMT-1 expression, enhanced miR-17~92 cluster expression, and attenuated pulmonary fibrosis."